A wildfire has burned 90% of the village that recorded Canada's highest ever temperature, the local MP says.
Brad Vis said the fire had caused extensive damage to Lytton, in British Columbia, and to surrounding critical infrastructure.
Lytton's mayor earlier ordered people to evacuate, saying flames had spread through the village in just 15 minutes.
The village this week recorded the country's highest ever temperature of 49.6C (121.3F).
Abnormally high temperatures have been recorded in swathes of North America.
British Columbia, in western Canada, recorded 486 deaths over five days compared with an average of 165 in normal times.
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Chief Coroner Lisa Lapointe blamed the extreme weather. The western province had seen only three heat-related deaths over the past three to five years.
media captionWatch: Canadians say the conditions are "unbearable"
Many of those who died, Ms Lapointe said, had been living alone in unventilated homes.
Temperatures have been easing in coastal areas of Canada but there is not much respite for inland regions. The weather system is now moving eastwards over the Prairie provinces - Alberta and Saskatchewan and parts of Manitoba have been placed under Environment Canada heat warnings.
Climate scientists are still trying to determine to what extent climate change may have aggravated the heatwave. One scientist, Zeke Hausfather, said the unprecedented weather was almost certainly a consequence of global warming.
"Climate is sort of steroids for the weather, it's loading the dice to make these sort of extreme events be more common," he told AFP news agency.
What is happening in Lytton?
Residents fled on Wednesday, many without their belongings, as smoke and flame engulfed the village, which is home to about 250 people and located about 260km (162 miles) north-east of Vancouver.
"The whole town is on fire," Mayor Jan Polderman told CBC News after signing the evacuation order at 18:00 on Wednesday (01:00 GMT Thursday).
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image captionThe speed of the fire in Lytton meant many people fled without their possessions
In one area, he said, "the fire was a wall about three, four feet high coming up to the fence line".
Winds of up to 71km/h (44 mph) were pushing the fire north into the community on Wednesday evening, CBC meteorologist Johanna Wagstaffe reported. Hot, dry and windy conditions in the area could mean the fire was moving at 10 or even 20km/h.
In a social media post on Thursday, MP Brad Vis said he would not be attending Canada Day activities because he was devoting all his time to the emergency situation.
"There are reports of several injuries. The situation is ongoing," he wrote.
Map showing the hottest areas in Canada and the US north-west
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Residents were being directed to nearby communities where reception centres were being set up, while the British Columbia Wildfire Service was diverting crews and equipment from other areas to respond to the fire.
Jean McKay, who left the First Nations community of Kanaka Bar, about 15km from Lytton, with her 22-year-old daughter Deirdre, told CBC how hard emotionally it had been to leave their home.
"I cried. My daughter cried. She said, 'I don't even know why I grabbed my key. We might not even have a home.' I said, 'Yeah I know. As long as we're together we'll survive.' I just pray that our houses are OK."
"You can't even comprehend it," Lytton evacuee Edith Loring-Kuhanga told CBC Radio. "Our entire town is gone."
Before the fire, Lytton had recorded the highest temperature ever seen in Canada on three consecutive days.
How dangerous was the heat elsewhere?
In Vancouver, British Columbia's biggest city, heat is believed to have been a contributing factor in the deaths of 65 people since Friday.
The city has opened 25 air-conditioned cooling centres where people have been resting or working from their laptops.
"I have no air conditioning, only a fan at home - I came here just to work where it's cool," one woman, who gave her name only as Lou, told AFP news agency.
Smoke rises from a wildfire at Long Loch and Derrickson Lake in Central Okanagan, British Columbia, Canada, June 30, 2021
image captionWildfires were also spotted in Central Okanagan, British Columbia
In the US state of Oregon, health officials tied more than 60 deaths to the extreme heat while in Washington State, 20 deaths were attributed to the weather, the Associated Press reports.
Seattle, Portland and other cities broke all-time heat records, which climbed above 46C in places.
Both Canadian Prime Minister Justin Trudeau and US President Joe Biden warned of the threat of wildfires, with Mr Biden telling governors of western US states it was as "severe as it's ever been".